Jesus’ disciples once asked Him what would “signal” His return and the end of the world as we know it.
In his reply, Jesus cautioned them not to assume that natural catastrophes such as famines or earthquakes or even man-made cataclysms such as wars meant the end of the age was just around the corner. Instead, He told His followers to view such catastrophic events as “the first of the birth pains, with more to come.”
Jesus’ caution is as applicable for us today as it was for His first disciples.
Every generation since the time of Jesus has had to deal with disasters of all types and scales. But there is no way for us to know when a recent disaster might signal the end of the world as we know it. Jesus Himself told His followers that only God knows for certain “the day or hour” when Christ will return.
Natural disasters do show us that the earth is not the way it’s supposed to be. It is groaning and longing for the day when Jesus returns and all of creation will be renewed. 
Earthquakes: Antioch, Syria, ad 525, 250,000 killed; Aleppo, Syria, 1138, 230,000 killed; Shaanxi Province, China, 1556, 830,000 killed. Famines: “Great Famine” of Europe, ad 1315–17, millions died; Indian famine of 1896–1902, millions died;
Chinese famine under Chairman Mao, 1958–61, 20-40 million died. 
In Jesus day, Jewish teachers, (including Jesus Himself) divided history into two ages; the “present age” and the “age to come”—the good news of God’s Kingdom coming to earth as it is in heaven that Jesus preached. Many who read the New Testament believe that these two ages began to overlap when Jesus rose from the dead, and that the “present age” will come to an end and the “age to come” will come in its fullness when Jesus returns to our present earth. Others believe that the “age to come” will not begin until this “present age” ends at the time of Christ’s return.